"This Could Arguably be the Biggest Medical Discovery Since Antibiotics" - Harvard Study

A newly discovered chemical--resveratrol--may hold the secret to our aging process.



Resveratrol, found in red wine and the skin of grapes, may hold the answer to one of the greatest questions of our time.


Have scientists finally discovered the fabled fountain of youth or a magical pill that will instantly melt all your fat away? Not quite, but impressive nonetheless, scientifically sound research from some of the world’s leading experts is showing that they may have actually come pretty close this time.

Dr. David Sinclair, Professor of Pathology at Harvard Medical School, was recently featured in a Barbara Walters investigative report where he explained that he believes to have "found one of the 'genetic keys' that will reset our biological clocks." After randomly testing tens of thousands of cells searching for a chemical that would activate age-controlling genes, Dr. Sinclair has finally found it.

What does this mean to the average American? According to experts, if we could just activate this gene with a certain chemical, we may be able to live significantly longer lives and feel and look younger, even at older ages.

Fortunately for us, the elusive switch that seems to turn that gene on has been identified—and it’s shaken the scientific and popular culture to the core. Everyone from PhD biochemists to Hollywood actresses have been quoted as saying they take Resveratrol daily.

We can’t blame them—as Dr. Sinclair's partner, biotechnical engineer Chris Westphal, explains: "We think that we can increase healthy lifespan so if you're in your 80s you'll be behaving as if you were in your 50s."

The new breakthrough supplement—Resveratrol—is derived from the skin of grapes, and is found in red wine.

How does Resveratrol work? Scientists explain that they believe resveratrol is so effective because it turns on (or "activates") the genes Dr. Sinclair identified, thereby causing your body to “mimic the effects of a low calorie diet without actually being on one.”

As it turns out, limited starvation may be one of the healthiest things you can do for yourself—even if you aren’t overweight—because it causes your body to activate these genes and switch into "survival mode." Unfortunately for us, however, starving ourselves isn’t the most appealing idea—no matter how healthy it might be--and we will do whatever we can to avoid it. That's where Resveratrol comes in--by supplementing with resveratrol, it looks like we may be able to reap those same benefits without the suffering.

While researching Resveratrol for this piece, we interviewed one biochemistry professor who has personally been taking Resveratrol for several years:

"After first reading the scientific literature on Resveratrol several years ago when it first started being mentioned in biochemistry journals and other 'advanced' publications, I was astounded. This wasn't some far-fetched, shot in the dark idea. There were concrete studies, concrete facts, and concrete science supporting the efficacy and potential for Resveratrol to change our lives. I was so impressed that I immediately began taking resveratrol myself on a daily basis (as have many other physicians and scientists) and I have even encouraged my children to be proactive and do the same."

In Barbara Walters' investigative report, she describes one experiment in which a mouse was given a high dose of resveratrol. According to Walters, that mouse quickly turned into a "mini Olympian, running twice as far as the untreated mouse...”

Dr. Sinclair elaborated that mice given resveratrol were able to eat "a high fat, fatty diet, and [live] just as long as a lean, healthy mouse, which means that they didn't get heart disease, cancer, even osteoporosis..." Sinclair also found that mice supplemented with Resveratrol usually "lived 30% longer" than their untreated counterparts, despite having that high calorie, high fat diet (further supporting the concept that resveratrol causes the body to act as if it were on a low calorie diet regardless of it actually being on one or not).

Is Resveratrol safe for humans? All signs point to yes--and it doesn't require a prescription. In fact, Barbara Walters’ report explained, “In the first human trial a form of resveratrol successfully treated type 2 diabetes."

Fortunately it is possible to get a trial bottle of Resveratrol by paying just 99 cents for them to ship your trial. You do need a coupon code, however, so when checking out be sure to enter "savings" in the promo code box.

Step 1: Get a Trial Bottle of Resveratrol by paying just $1.99 to cover some of the shipping costs.

Resveratrol (trans-resveratrol) is a phytoalexin produced naturally by several plants when under attack by pathogens such as bacteria or fungi. Resveratrol has also been produced by chemical synthesis and is sold as a nutritional supplement derived primarily from Japanese knotweed. In mouse and rat experiments, anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects of resveratrol have been reported. Most of these results have yet to be replicated in humans. In the only positive human trial, extremely high doses (3–5 g) of resveratrol in a proprietary formulation have been necessary to significantly lower blood sugar. Resveratrol is found in the skin of red grapes and is a constituent of red wine, but apparently not in sufficient amounts to explain the French paradox. Experiments have shown that resveratrol treatment extended the life of fruit flies, nematode worms and short-lived fish but it did not increase the life span of mice.

Life extension
The groups of Howitz and Sinclair reported in 2003 in the journal Nature that resveratrol significantly extends the lifespan of the yeast Saccharomyces cerevisiae. Later studies conducted by Sinclair showed that resveratrol also prolongs the lifespan of the worm Caenorhabditis elegans and the fruit fly Drosophila melanogaster. In 2007, a different group of researchers was able to reproduce Sinclair's results with Caenorhabditis elegans, but a third group could not achieve consistent increases in lifespan of D. melanogaster or C. elegans.

Cancer prevention
In 1997, Jang reported that topical resveratrol applications prevented skin cancer development in mice treated with a carcinogen. There have since been dozens of studies of the anti-cancer activity of resveratrol in animal models. No results of human clinical trials for cancer have been reported. However, clinical trials to investigate the effects on colon cancer and melanoma (skin cancer) are currently recruiting patients.

Mechanisms of action
The mechanisms of resveratrol's apparent effects on life extension are not fully understood, but they appear to mimic several of the biochemical effects of calorie restriction. Some studies indicates that resveratrol activates Sirtuin 1 (SIRT1) and PGC-1α and improve functioning of the mitochondria. Other research calls into question the theory connecting resveratrol, SIRT1, and calorie restriction. In addition resveratrol's ability to directly activate sirtuin 1 has been called into question.

 

  

Resveratrol was recently featured by Barbara Walters in a special report. [Note: Barbara Walters is not endorsing any specific resveratrol brand or manufacturer in her report. The video featured above simply describes the chemical itself.]


Step 1:

First get a trial bottle of Resveratrol by paying just $1.99 in shipping to cover the costs.

 



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Plants and foods
Resveratrol was originally isolated by Takaoka from the roots of white hellebore in 1940, and later, in 1963, from the roots of Japanese knotweed. However, it attracted wider attention only in 1992, when its presence in wine was suggested as the explanation for cardioprotective effects of wine.
In grapes, resveratrol is found primarily in the skin, and—in muscadine grapes—also in the seeds. The amount found in grape skins also varies with the grape cultivar, its geographic origin, and exposure to fungal infection. The amount of fermentation time a wine spends in contact with grape skins is an important determinant of its resveratrol content.
The levels of resveratrol found in food varies greatly. Red wine contains between 0.2 and 5.8 mg/L, depending on the grape variety, while white wine has much less—the reason being that red wine is fermented with the skins, allowing the wine to absorb the resveratrol, whereas white wine is fermented after the skin has been removed. A number of reports have indicated that muscadine grapes may contain high concentrations of resveratrol and that wines produced from these grapes, both red and white, may contain more than 40 mg/L. However, subsequent studies have found little or no resveratrol in different varieties of muscadine grapes.